SWISS uses its six Airbus A321 aircraft on European routes and to North Africa and the Middle East.

The Airbus A321 is the 'big brother' of the A320 family; it is one-third longer than the Airbus A319. Depending on the number of business class passengers (the middle seat is blocked off in business), the Airbus A321 seats between 176 and 200 passengers.

In economy, the seating configuration is 3-3, (A,B,C - D,E,F). In business, it is 2-2, with the middle seat blocked, so it is A,C - D,F.