Qantas uses its fleet of wide-body Boeing 767-300s on domestic and international routes. It fits them in seven different seating arrangements, though all are two class (economy and business).

Most business class cabins feature 30 seats, although one version has only 25. The number of economy seats ranges from 204 to 224. These aircraft are often referred to with the ticketing code 767-336 or -338.

Qantas began refurbishing 16 of its domestic B767s in October 2012, with new leather seat covers and pre-loaded iPads for in flight entertainment provided to all customers.